- Cellular processes such as inflammation, cell differentiation and tumor cell migration.
- Clearance of apoptotic cells, such as in autoimmune diseases
- Splicing results in multiple transcript variants that encode the same protein.
- Antibodies that neutralize HMGB1 can be used to protects against damage and tissue injury during arthritis, lupus erythematosus, colitis, sepsis, endotoxemia, and ischemia.
- thermodynamic stability with electrostatic interactions between the acidic tail and the HMG box.
- The C-terminal acidic tail of HMGB1 helps in the maintenance of protein stability.
- Affibody AB
- Cantex Pharmaceuticals Inc
- Dicerna Pharmaceuticals Inc
- Evec Inc
- Ribomic Inc
- Autoimmune Disorders
- Cerebral Infarction
- Chemotherapy Effects
- Cancer Treatment
- Dociparstat Sodium
- RBM-005
- EV-007156
-
North America
- U.S.A
- Canada
- Europe
- France
- Germany
- Spain
- UK
- Rest of Europe
- Asia Pacific
- China
- Japan
- India
- South East Asia
- Latin America
- Brazil
- Middle East and Africa
- Market Forecast for
- Market growth drivers
- Challenges and Opportunities
- Emerging and Current market trends
- Market player Capacity, Production, Revenue (Value)
- Supply (Production), Consumption, Export, Import analysis
- End-user/application Analysis
- Market Forecast for 2024-2030
- Market growth drivers
- Challenges and Opportunities
- Emerging and Current market trends
- Market player Capacity, Production, Revenue (Value)
- Supply (Production), Consumption, Export, Import analysis
- End user/application Analysis
High Mobility Group Protein B1 Market Analysis & Forecast 2024-2030
High Mobility Group Protein B1 Market by Product Type (Dociparstat Sodium, RBM-005, EV-007156) by Application / End /User (Autoimmune Disorders, Cerebral Infarction, Chemotherapy Effects, Cancer) Industry Analysis, Volume, Share, Growth,Challenges,Key Players, Trends, Regions and Forecast 2024-2030, Regional Outlook ( North America, Europe, Asia-Pacific, Middle-East, Africa)
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Table of Contents
High Mobility Group Protein B1 (HMGB1) also known as High mobility group box 1 or SBP-1 is protein encoded by HMGB1 gene. HMGB1 is secreted by immune cells such as monocytes, macrophages, and dendritic cells through leaderless secretory pathway. Activated macrophages and monocytes secrete HMGB1. High Mobility Group Box protein 1 (HMGB1) is a non-alkaline (non-histonic) DNA-binding protein, it is normally localized in the nucleus as part of the chromatin. High Mobility Group Protein B1 is member of chromatin proteins which also includes, HMG1, HMG 2, HMG 14, and HMG 17.
HMGB1 with its high positive charge binds to DNA leads to oxidation, hyperacetylation and posttranslational modifications. HMGB1 is responsible for Stabilization of the nucleosomal structure and regulation of gene transcription in chromatin. It is released by necrotic cells hence act as chaperone to shuttle nuclei acids into the endosomal compartment of APCs. Nucleic acid sensors like TLR9 trigger due to High Mobility Group Protein B1 (HMGB1) . HMGB1 also has the ability to bind LPS, at the level of lipid A, possibly because of its high positive electric charge. It can chaperone to the CD14-TLR4 MD2 complex, increasing the response of macrophages to the LPS.
High Mobility Group Protein B1 (HMGB1) has its importance in:
High Mobility Group Protein B1 Market : Key Player
High Mobility Group Protein B1 Market: End User / Application Type
High Mobility Group Protein B1 Market : Product Type
Global High Mobility Group Protein B1 Market: Regional Analysis
High Mobility Group Protein B1 Market Report delivers a comprehensive analysis of the following parameters :
Global High Mobility Group Protein B1 Market Report delivers a comprehensive analysis of the following parameters:
Report Coverage
| Parameters | Details |
|---|---|
Base Year |
2023 |
|
Historical Data |
2018-2023 |
|
Forecast Data |
2024-2030 |
|
Regional Scope |
North America, Europe, Asian Pacific, Latin America, Middle East and Africa, and ROW |
Frequently Asked Questions (FAQ)
High Mobility Group Protein B1 Market report considers 2023 as the base year.
High Mobility Group Protein B1 Market report considers data for period 2018 to 2023 as the historical data and forecast between 2024 to 2030.
Yes, report is inclusive in-detailed analysis of key players in High Mobility Group Protein B1 Market
High Mobility Group Protein B1 Market The study mainly includes analysis for North America, Europe, Asia Pacific, Latin America, Middle East and Africa, and ROW. Also, analysis is further drop-down to country level.
High Mobility Group Protein B1 Market Report includes Market Segmentation, Regional outlook, Application Analysis, Competitive analysis, Supply-Demand Analysis, Market Size, Trends, Strategies, and Forecast.
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